The story begins with Andre Bishop's promising boxing career getting derailed due to false accusations of assault. As a result, Bishop finds himself stripped of his title, facing legal troubles, and serving time in prison. While incarcerated, he catches the attention of a former boxing trainer named Gus Carisi, who believes in his talent and sees the potential for redemption.
With Gus as his mentor, Andre returns to the boxing world and embarks on a path of redemption and triumph. The game takes players through a series of fights, showcasing the physical and mental challenges faced by a professional boxer. Along the way, Andre encounters various opponents, each with their own unique styles and strengths.